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KBN2202 modulates amyloidogenic protein levels in the hippocampus of 5xFAD mice. ( a – d ) Representative immunoblots of full-length APP ( a ), APP C-terminal fragments (APP-CTFs) ( b ), BACE1 ( c ), and PS1 ( d ) in hippocampal lysates from vehicle (Veh)- and KBN2202-treated (5 or 20 mg/kg) mice. ( e – h ) Densitometric quantification of APP ( e ), APP-CTFs ( f ), BACE1 ( g ), and PS1 ( h ) protein levels normalized to GAPDH. APP-CTFs were reduced in both KBN2202-treated groups compared with Veh controls, whereas full-length APP, BACE1, and PS1 levels remained unchanged across groups. Data were obtained from three independent experiments using hippocampal samples ( n = 4 per group). Data are shown as individual points using box-and-whisker plots (median with minimum–maximum range). * p < 0.05 and ** p < 0.01 vs. Veh; one-way ANOVA followed by Dunnett’s post hoc test.

Journal: International Journal of Molecular Sciences

Article Title: KBN2202, a Salicylic Acid Derivative, Preserves Neuronal Architecture, Enhances Neurogenesis, Attenuates Amyloid and Inflammatory Pathology, and Restores Recognition Memory in 5xFAD Mice at an Advanced Stage of AD Pathophysiology

doi: 10.3390/ijms262210942

Figure Lengend Snippet: KBN2202 modulates amyloidogenic protein levels in the hippocampus of 5xFAD mice. ( a – d ) Representative immunoblots of full-length APP ( a ), APP C-terminal fragments (APP-CTFs) ( b ), BACE1 ( c ), and PS1 ( d ) in hippocampal lysates from vehicle (Veh)- and KBN2202-treated (5 or 20 mg/kg) mice. ( e – h ) Densitometric quantification of APP ( e ), APP-CTFs ( f ), BACE1 ( g ), and PS1 ( h ) protein levels normalized to GAPDH. APP-CTFs were reduced in both KBN2202-treated groups compared with Veh controls, whereas full-length APP, BACE1, and PS1 levels remained unchanged across groups. Data were obtained from three independent experiments using hippocampal samples ( n = 4 per group). Data are shown as individual points using box-and-whisker plots (median with minimum–maximum range). * p < 0.05 and ** p < 0.01 vs. Veh; one-way ANOVA followed by Dunnett’s post hoc test.

Article Snippet: Membranes were blocked in 3% bovine serum albumin (BSA) and incubated overnight at 4 °C with primary antibodies against full-length APP (rabbit monoclonal, 1:2000, Cell Signaling Technology, #29765), APP-CTFs (rabbit polyclonal, 1:1000, Sigma-Aldrich, A8717), BACE1 (rabbit monoclonal, 1:1000, Abcam, ab183612), PS1 (rabbit monoclonal, 1:1000, Cell Signaling Technology, 5643), DCX (rabbit polyclonal, 1:1000, Abcam, ab18723) and β-actin or glyceraldehyde 3-phosphate dehydrogenase (GAPDH) (mouse monoclonal, 1:2000, Santa Cruz Biotechnology, sc-47778 or sc-32233, Dallas, TX, USA).

Techniques: Western Blot, Whisker Assay